Tag Archives: Gattaca

Genetics: Faking DNA

DNA_mknowles_FlickrIn Gattaca, the demand for genetic perfection drives genetic deception: people use substitute DNA to disguise their “inadequacies.”

The method in Gattaca was relatively simple: the “perfect,” impostor blood was put in a fake fingertip, so that an automatic sampler would take the wrong blood.

Now a team of scientists has already gone further, the New York Times reports. The team “fabricated blood and saliva samples containing DNA from a person other than the donor of the blood and saliva. They also showed that if they had access to a DNA profile in a database, they could construct a sample of DNA to match that profile without obtaining any tissue from that person.”

In other words, “any biology undergraduate” (in their words) could use a DNA profile to make fake genetic evidence, tying the victim to a place or activity they had nothing to do with.

For now, this method would not allow faking the full genome, but it is likely that if certain characteristics were being sought in a sample in the future, this or a similar technology could fake them by then.

(Thanks to Christopher Kent for the tip.)

(Image courtesy mknowles, Flickr)

My Comment on Genetics in Wired

wiredukThe new British version of Wired included a comment from me on genetics.

“We expect that this price will continue to drop, making some form of genetic analysis accessible to large numbers of people within the next decade,” [Linda Avey] says. Tamar Kasriel likens sequencing to a “Damocletian threat”, but Josh Calder disagrees. “The list of things we can partially prevent or prepare for is going to grow long enough that we’re going to want to do it.”

I’m not actually disagreeing with Kasriel: some ways that we could pursue genetic knowledge and biotech are indeed deeply threatening. I just suspect that collectively we are going to want to use that knowledge to prevent suffering, and that will almost inevitably blur into improvements (even if we don’t go as far as Gattaca), with different people and cultures disagreeing about the desirable and permissible boundaries of this use of genetics.