Category Archives: Biotechnology

Genetics: Faking DNA

DNA_mknowles_FlickrIn Gattaca, the demand for genetic perfection drives genetic deception: people use substitute DNA to disguise their “inadequacies.”

The method in Gattaca was relatively simple: the “perfect,” impostor blood was put in a fake fingertip, so that an automatic sampler would take the wrong blood.

Now a team of scientists has already gone further, the New York Times reports. The team “fabricated blood and saliva samples containing DNA from a person other than the donor of the blood and saliva. They also showed that if they had access to a DNA profile in a database, they could construct a sample of DNA to match that profile without obtaining any tissue from that person.”

In other words, “any biology undergraduate” (in their words) could use a DNA profile to make fake genetic evidence, tying the victim to a place or activity they had nothing to do with.

For now, this method would not allow faking the full genome, but it is likely that if certain characteristics were being sought in a sample in the future, this or a similar technology could fake them by then.

(Thanks to Christopher Kent for the tip.)

(Image courtesy mknowles, Flickr)

Legal Issues of the Future

Justice by Billogs (Flickr)As the Sotomayor hearings went on this week, I talked to a reporter about legal issues that a justice might see in the next 25 years, going beyond our present obsessions. (I did not actually say that senators should ask Sotomayor about them.)

Topics included:

  • virtual reality
  • artificial intelligence
  • genetic engineering and human enhancement
  • brain technology
  • human-animal hybrids

About artificial intelligence, I said, in part:

“People have been talking about the possibility of a “singularity” (in which artificial intelligence becomes sentient) in a couple of decades. It involves two questions: if something says it’s sentient, do we believe it? And if so, do we care? It may be more of a question if it involves a biological system. Does something require a biological brain to be human?”

(Image courtesy Billogs, Flickr)

Breeding Superapes?

The monkeys are comingNot exactly. But last month scientists announced that monkeys had passed genetic modifications to their offspring for the first time.

Planet of the Apes it is not; the genetic modifications merely cause the monkeys to glow green under fluorescent light.

But it is another step toward the world of Gattaca: we have achieved heritable modifications with primates, and the “same techniques would be used on chimps or other primates even closer to humans or to try to endow people with desirable genetic traits,” the article noted.

Source: Rob Stein, “Monkeys first to inherit genetic modifications,” SFGate.com, May 28, 2009. Image copyright FutureAtlas.com — usable with link and attribution

My Comment on Genetics in Wired

wiredukThe new British version of Wired included a comment from me on genetics.

“We expect that this price will continue to drop, making some form of genetic analysis accessible to large numbers of people within the next decade,” [Linda Avey] says. Tamar Kasriel likens sequencing to a “Damocletian threat”, but Josh Calder disagrees. “The list of things we can partially prevent or prepare for is going to grow long enough that we’re going to want to do it.”

I’m not actually disagreeing with Kasriel: some ways that we could pursue genetic knowledge and biotech are indeed deeply threatening. I just suspect that collectively we are going to want to use that knowledge to prevent suffering, and that will almost inevitably blur into improvements (even if we don’t go as far as Gattaca), with different people and cultures disagreeing about the desirable and permissible boundaries of this use of genetics.

A good cloning movie at last?

Clones Bosslyn FlickrNever Let Me Go is about to start filming, with Keira Knightly in the lead role.

It is based on the Kazuo Ishiguro novel by the same name, and if it retains half of the book’s seriousness, it may be the first solid cloning movie since The Boys from Brazil.

The topic has typically been dealt with at the level of pure sensationalism, as in The Sixth Day, or obscured with a quasi-mystical veneer, as in The Island.

Image courtesy Bosslyn (Flickr) — usable with attribution